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Presenting Author(s) Gail Martin
Abstract Title

FGF signaling in the limb: a genetic analysis.

Full author List Gail Martin, Christina Ahn, Pengfei Lu, George Minowada
Text of abstract Four of the 22 known mouse FGF genes, Fgf4, Fgf8, Fgf9 and Fgf17, display AER-specific expression domains within the normal mouse limb bud (AER-FGFs). Fgf8 is unique among these genes, because it is expresse d ~12-18 hours earlier than the others and because it is the only one that, when individually inactivated, causes abnormal limb development. We have explored the functions of the different AER-FGFs by producing mice in which they have been inactivated pairwise, or in threes. The data have led us to propose a model of AER-FGF activity in which they function to ensure that sufficient skeletal progenitors are available to form skeletal elements of normal number/size. Fgf8 is more important than the other AER FGFs only because it is expressed earlier and influences the size of the nascent limb bud, and thus the initial sizes of the skeletal progenitor populations. However, it does not have a unique biochemical function, and can be functionally replaced by Fgf4. The other AER-FGFs, which are expressed later, influence the final sizes of the skeletal progenitor populations.
Which session is your work most relevant to: Limb patterning