|Presenting Author(s)||Toshihiko Ogura|
|Abstract Title||Tbx genes and body plans of vertebrate embryos. - Paradigm and perspective of development and evolution -|
|Full author List||Toshihiko Ogura|
|Text of abstract||
T-box (Tbx) genes play key roles d uring organogenesis and pattern formation in both vertebrate and inve rtebrate embryos. They encode a group of transcription factors char acterized by a highly conserved DNA-binding motif (T-box) and its unusual mode of DNA recognition. By a combination of embryological and g enetic approaches, a picture is emerging that Tbx genes belong to highly conserved genetic networks.
Tbx2, Tbx3, Tbx4 and Tbx5 genes are derived from a common ancestral gene, which gave rise to a small gene complex by two duplication events during evolut ion of tetrapod animals. Due to heterotopic and heterochronic evolu tion, these four Tbx genes show unique and definitive expression in vari ous tissues, such as limb buds, retina and hearts. Recent studies have shown that the diversification of these Tbx genes has been involved in the evolution of body plans.I will present data on the funct ional roles played by these Tbx genes during vertebrate limb and hear t development. By discussing an overview, I would like to highlight t he Tbx genes as key players for the evolution and the diversification of vertebrate body plans.
|Which session is your work most relevant to:||Limb evolution|
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