Logo Abstract Information


Presenting Author(s) Cliff Tabin
Abstract Title Patterning the early limb axes.
Full author List Brian Harfe, Paul Scherz, Jacquie Campbell, Andy Dudley, Richard Pearse, Amitabha Bandyopadhyay, Jennifer Mansfield
Text of abstract Our laboratory has undertaken a number of studies to elucidate the patterning of the early limb bud. Recent approaches have included detailed lineage analysis in the early limb bud using retroviral vectors in chick, recombinase-based fate mapping of former ZPA cells in mouse, bead implant studies to elucidate the breakdown of Shh-Fgf cross-signalling in chick, genetic studies of the roles of BMPs as secondary signals in AP axis formation in mouse, and studies of the roles of endogenous microRNAs in regulating gene activity in the limb bud. Some of the more intriguing results from these studies will be presented.
Which session is your work most relevant to: Limb patterning