|Presenting Author(s)||Mikiko Tanaka|
|Abstract Title||Developmental genetic basis of the evolution of pelvic fin loss in pufferfish Fugu rubripes.|
|Full author List||Mikiko Tanaka, Laura A Hale, Angel Amores, Yi-Lin Yan, William A Cresko, Tohru Suzuki and John H Postlethwait|
|Text of abstract||
The pelvic fins are located in the lower part of the flank and are homologous with the posterior appendages of the tetrapods. During evolution of fishes, the pelvic fins may move forward, become reduced, or even be entirely lost. We have approached the mechanisms for the evolution of pelvic fin loss, using Japanese pufferfish (Fugu rubripes) as a model organism.Japanese pufferfish, Fugu rubripes, has the fewest vertebrae among animals with backbones, and no pelvic fins. We are investigating the genetic basis of limb loss in Fugu. We hypothesize that Fugu has a mutation in either a gene needed for hindlimb development, or in a hindlimb-specific regulatory element of a gene essential for limb developmental in general. We tested this by obtaining Fugu orthologues of vertebrate genes essential for limb positioning, initiation, and outgrowth, and examined their expression pattern in Fugu embryos. These profiles of gene expression allow us to select candidate genes for further analyses, such as identification of regulatory elements regulating fin specific expression by genome comparison.
|Which session is your work most relevant to:||Limb evolution|
© Copyright 2003 The Medical Research Council Human Genetics Unit
All Rights Reserved